EGCG and Triple Negative Breast Cancer

EGCG (Epigallocatechin-3-Gallate), the major active component of green tea, has anti-cancer effect on breast cancer cells.

EGCG and Triple Negative Breast Cancer subdues cancer growth

Researchers exposed triple negative breast cancer cells to EGCG. They found EGCG subdues the growth, metastasis and spreading of triple negative breast cancer cells by decreasing blood vessel growth to breast cancer cells and tumors. The anti-cancer effect was seen at 24, 48 and 72 hours after treatment. [1]

The same researchers previously found EGCG caused significant death of triple negative breast cancer cells at 48 and 72 hours after treatment in their laboratory. EGCG upregulated 18 and down regulated 4 cancer growth genes including BAG3, XIAP, RIPKS. These genes may be associated with resistance to cancer treatment. [2]

High doses work better than low doses of EGCG in treating triple negative breast cancer. High doses caused oxidative damage, similar to chemotherapy drugs. [3]

At the time of publication, the amount of EGCG and triple negative breast cancer research is limited due to 2 facts:

Triple negative breast cancer is not common, even though is may be a problem for you. Since it is not at common researchers can not get as much money.

EGCG is an inexpensive natural product and financially cannot be developed for prescription drug use.

Newer breast cancer research is finding combining curcumin with EGCG enhances the effectiveness of the natural treatments in preventing cancer stem cell growth [4] although the combination has not been tested in triple negative breast cancer. Click pr tap here to learn more about triple negative breast cancer and curcumin treatment.

Taking EGCG with piperine (BioPerine) increases the blood level of EGCG in the body. [5] Xymogen CurcuPlex has Bioperine.

[1] Journal of Nanoscience and Nanotechnology. 2013 Jan;13(1):632-7. Epigallocatechin-3-Gallate (EGCG) inhibits cell proliferation and migratory behaviour of triple negative breast cancer cells. Braicu C1, Gherman CD, et al.
http://www.ncbi.nlm.nih.gov/pubmed/23646788

[2] Journal of Drug Targeting. 2012 Nov 19. Epigallocatechin gallate induce cell death and apoptosis in triple negative breast cancer cells Hs578T. Braicu C1, Gherman C. http://informahealthcare.com/doi/abs/10.3109/1061186X.2012.740673

[3] International Journal of Molelular Science. 2011;12(12):9342-53. The relationships between biological activities and structure of flavan-3-ols. Braicu C1, Pilecki V, et al. http://www.mdpi.com/1422-0067/12/12/9342

[4] Anticancer Res. 2015 Jan;35(1):39-46. Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling. Chung SS1, Vadgama JV2. 1Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, U.S.A. , 2Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, U.S.A. Jonson Comprehensive Cancer Center, Los Angeles, CA, U.S.A. UCLA Department of Medicine, Los Angeles, CA, U.S.A. http://ar.iiarjournals.org/content/35/1/39.long

[5] Journal of Nutrition. 2008 Aug;138(8):1529S-1534S. Nongallated compared with gallated flavan-3-ols in green and black tea are more bioavailable. Henning SM1, Choo JJ, Heber D. Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA. http://jn.nutrition.org/content/138/8/1529S.long

EGCG (Epigallocatechin-3-Gallate), the major active component of green tea, has anti-cancer effect on breast cancer cells.

Resveratrol Cancer: Resveratrol has been shown to prevent cancer formation and prolong lifespan.